项目: 1、国家自然科学基金青年项目:基于“效-构-量”导向的疏风解毒胶囊体内过程研究(81703802),2018.1-2020.12,20万元,主持; 2、天津市自然科学基金青年项目:基于“传递导向-质效关联”策略的丹红化瘀口服液质量标志物研究(19JCQNJC12700),2019.4-2022.3,6万元,主持; 3、广西中药药效研究重点实验室开放课题:中药姜黄的质量标志物研究(20-065-38-K5),2020.10-2021.10,5万元,主持; 4、天津市自然科学基金面上项目:基于构/量差异的元胡止痛方多成分药代动力学研究(16JCYBJC28300),2016.4-2019.3,10万元,第二; 论文: 1、Zhang Hongbing, Zhang Yu, Zhang Tiejun*, Liu Changxiao*, Research progress on quality markers of traditional Chinese medicine, Journal of Pharmaceutical and Biomedical Analysis, 2022, 211: 114588. 2、Zhang Hongbing#, Wu Xin#, Xu Jun, Gong Suxiao, Han Yanqi, Zhang Tiejun*, Liu Changxiao*, The comparative pharmacokinetic study of Yuanhu Zhitong prescription based on five quality-markers, Phytomedicine, 2018, 44: 148-154. 3、Wu Xin#, Zhang Hongbing#, Fan Shanshan, Zhang Yidan, Yang Zhen, Fan Simiao, Zhuang Pengwei*, Zhang Yanjun*, Quality Markers Based on Biological Activity: A New Strategy for the Quality Control of Traditional Chinese Medicine, Phytomedicine, 2018, 44: 103-108. 4、Zhang Hongbing, Wu Xin, Liu Xinyi, Xu Jun, Gong Suxiao, Han Yanqi, Zhang Tiejun*, Liu Changxiao*, Quality transitivity of Danhong Huayu Koufuye: A study on chemical profiles of medicinal herbs, compound preparation and dosed rat plasma using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry, Biomedical Chromatography, 2020, 34: e4813. 5、Liu Xinyi#, Zhang Hongbing#, Xu Jun, Gong Suxiao, Han Yanqi, Zhang Tiejun*, Liu Changxiao*, Identification of absorbed components and their metabolites in rat plasma after oral administration of Shufeng Jiedu Capsule using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry, Rapid Communications in Mass Spectrometry, 2019, 33: 1494-1501. 获奖: 1、天津市科技进步一等奖(2021),中药质量标志物理论创建与关键技术创新及其应用,第九。 2、刘昌孝人才奖(2017),优秀博士生奖,第一。 |