项目: 1、国家自然科学基金青年科学基金项目:基于低共熔溶剂的药物共晶合成及其机制研究(22101204),2022.01-2024.12,30万,第一; 2、国家自然科学基金面上项目:抗肿瘤药-药纳米共晶的可控合成与增溶增效研究(22271220),2023.01-2026.12,54万,第三; 3、横向课题:甾体激素类药物共晶的固态分析研究,5万,第一。 论文: 1. Guan-Lan Huang1, Ling Yang1, Bo-Ying Ren, Xin-Yue Lv, Ling-Yi Song, Xia-Lin Dai*, Jia-Mei Chen*, Simultaneously Improving the Physicochemical and Pharmacokinetic Properties of Vemurafenib through Cocrystallization Strategy. J. Drug Deliv. Sci. Tec. 2022, 70, 103230. 2. Jun-Long Jia, Xia-Lin Dai,* Hao-Jie Che, Meng-Ting Li, Xiao-Mei Zhuang, Tong-Bu Lu and Jia-Mei Chen,* Cocrystals of Regorafenib with Dicarboxylic Acids: Synthesis, Characterization and Property Evaluation. CrystEngComm 2021, 23, 653−662. 3. Jie Wang, Xia-Lin Dai,* Tong-Bu Lu and Jia-Mei Chen,* Temozolomide−Hesperetin Drug−Drug Cocrystal with Optimized Performance in Stability, Dissolution, and Tabletability. Cryst. Growth Des. 2021, 21, 838−846. 4. Bo-Ying Ren, Xia-Lin Dai,* Jie Wang, Chao Wu, Tong-Bu Lu and Jia-Mei Chen*, Cocrystallization of Axitinib with Carboxylic Acids: Preparation, Crystal Structures and Dissolution Behavior. CrystEngComm 2021,23, 5504−5515. 5. Xia-Lin Dai, Jia Yao, Jun-Hui Deng, Yong-Hui Mo, Tong-Bu Lu and Jia-Mei Chen,* Solubility and Permeability Improvement of Allopurinol by Cocrystallization. Cryst. Growth Des. 2020, 20, 5160−5168. 6. Xia-Lin Dai, Chao Wu, Jin-Hui Li, Lian-Chao Liu, Xin He, Tong-Bu Lu and Jia-Mei Chen,* Modulating the Solubility and Pharmacokinetic Property of 5-Fluorouracil via Cocrystals. CrystEngComm 2020, 22, 3670−3682. 7. Xia-Lin Dai, Alexander P. Voronin, Yong-Liang Huang, German L. Perlovich, Xing-Hua Zhao, Tong-Bu Lu and Jia-Mei Chen,* 5-Fluorouracil Cocrystals with Lipophilic Hydroxy-2-Naphthoic Acids: Crystal Structures, Theoretical Computations and Permeation Studies. Cryst. Growth Des. 2020, 20, 923−933. 8. Xia-Lin Dai, Alexander P. Voronin, Wei Gao, German L. Perlovich, Tong-Bu Lu and Jia-Mei Chen,* Intermolecular Interactions and Permeability of 5-Fluorouracil Cocrystals with a Series of Isomeric Hydroxybenzoic Acids: a Combined Theoretical and Experimental Study. CrystEngComm 2019, 21, 5095−5105. 9. Xia-Lin Dai, Jia-Mei Chen* and Tong-Bu Lu,* Pharmaceutical Cocrystallization: an Effective Approach to Modulate the Physicochemical Properties of Solid-State Drugs. CrystEngComm 2018, 20, 5292−5316. 10. Xia-Lin Dai, Song Li, Jia-Mei Chen* and Tong-Bu Lu, Improving the Membrane Permeability of 5‑Fluorouracil via Cocrystallization. Cryst. Growth Des. 2016, 16, 4430−4438. 专利: 1. 陈嘉媚,吕文婷,戴霞林,一种奥拉帕尼与马来酸的共晶及其制备方法,中国发明专利,申请日2020.7.22,授权公告日2021.12.3,专利号202010708667.2。 2. 陈嘉媚,贾军龙,戴霞林,授权公告日2021.12.3,一种瑞戈非尼与马来酸的共晶及其制备方法,中国发明专利,申请日2020.8.7,授权公告日2021.12.3,专利号202010787157.9。 3. 戴霞林,吕文婷,陈嘉媚,一种奥拉帕尼与丙二酸的共晶及其制备方法,专利号202010707895.8。 4. 戴霞林,贾军龙,李梦婷,陈嘉媚,一种瑞戈非尼与辛二酸的共晶及其制备方法,专利号202010702741.X。 |